Are you wondering which fonts are the most installed in all the platforms (Mac, Linux, Windows)?
Do you want to use a signature with a font but being sure that the appearancence won’t change a lot?
AVOID SURPRISES
These are the most “universal” – compatible font-family you can use:
font-family:Arial, Helvetica, sans-serif;
font-family:"Times New Roman", Times, serif;
font-family:"Courier New", Courier, monospace;
font-family:Georgia, "Times New Roman", Times, serif;
font-family:Verdana, Arial, Helvetica, sans-serif;
Someone suggests also to use:

font-family: Trebuchet MS,Lucida Grande,Lucida Sans Unicode,Lucida Sans,Tahoma,sans-serif;
font-family: ‘Lucida Sans Unicode’, ‘Lucida Grande’, sans-serif;
font-family: ‘Palatino Linotype’, ‘Book Antiqua’, Palatino, serif;
Disclaimer: this is a fast guide, a tutorial, an how-to article that I personally wrote for you. Feel free to write here any kind of suggestion! It is helpful if you need to solve your problem, if you need a tip or if you are in trouble and you need an help!